Based on the lightning monitoring data of 33 lightning location monitoring stations and real-time lightning disaster data of 48 counties in Qinghai Province from 2010 to 2019, the spatial distribution and risk zoning of lightning disasters in Qinghai Province were analyzed by using mathematical statistics and ArcGIS spatial analysis method. The results show that the regions with more lightning frequency and strong positive and negative lightning current intensity were mainly distributed in the central and eastern part of Qinghai Province, while the areas with high value of thunderstorm days were mainly distributed in the Qilian Mountain and the southern part of Qinghai Province. The lightning disaster risk presented obvious regional differentiation in Qinghai Province. The high-risk regions were mainly located in Kunlun Mountains, Qilian Mountains, Nyainqentanglha Mountains, Bayan Har Mountains and Anyemaqen Snowy Mountains, as well as part of the southern grazing area of Qinghai Province. The northwest of Qaidam Basin, the southeast pastoral area of Qinghai Province and some areas around Qinghai Lake were medium-risk areas. The risk level in most of the eastern agricultural area, part of Qaidam Basin, Wudaoliang and Tuotuo River area was relatively lower.